{"created":"2023-05-15T14:57:05.482407+00:00","id":77471,"links":{},"metadata":{"_buckets":{"deposit":"c85df137-b9a4-41c1-bda1-f5b4e0c7811d"},"_deposit":{"created_by":1,"id":"77471","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77471"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077471","sets":["10:27"]},"author_link":["822179","822180"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperpolarization is a quantum technology to enhance the sensitivity of nuclear magnetic resonance (NMR). The hyperpolarized (HP) chemical probe, which is a low molecular mass compound labeled with an NMR-positive nuclei like 13C or 15N, is dissolved in a glassing agent (e.g. glycerol/H2O) doped with a stable radical compound (OX063, etc.). The sample mixture is conditioned in a polarizing system (e.g. 3.35 Tesla, -271.6 °C, 2.8 mbar), and irradiation of the unpaired electrons with microwaves (e.g. 94 GHz, 100 mW) transfers the spin polarization from the electrons to the nuclei through the Overhauser effect. Using a superheated solvent (~200 °C), the polarized sample mixture is immediately dissolved by warming up to around biological temperature, and then quickly transferred for NMR/MRI acquisition. The chemical shift change of NMR-positive nuclei, which is induced upon the structural conversion of the HP chemical probe as a tracer, can be observed in real-time depending on the enhanced NMR signals over 4 orders of magnitude (>10,000-fold). Following the development of functional HP chemical probes and surrounding options, this technology is currently being applied to non-invasive NMR spectroscopy for direct monitoring of cell metabolism, MRI metabolic imaging of various disease animal models, and patients with cancer. \n  In this symposium, a brief overview of the HP-NMR/MRI will be presented, focusing on the application in radiation research as well as the current topics and future directions of this technology.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第 62 回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高草木, 洋一"}],"nameIdentifiers":[{"nameIdentifier":"822179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"822180","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線研究における超偏極−核磁気共鳴分光法とイメージングの応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線研究における超偏極−核磁気共鳴分光法とイメージングの応用"}]},"item_type_id":"10005","owner":"1","path":["27"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-18"},"publish_date":"2019-11-18","publish_status":"0","recid":"77471","relation_version_is_last":true,"title":["放射線研究における超偏極−核磁気共鳴分光法とイメージングの応用"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:16:36.505456+00:00"}