@misc{oai:repo.qst.go.jp:00077471,
 author = {高草木, 洋一 and Takakusagi, Yoichi},
 month = {Nov},
 note = {Hyperpolarization is a quantum technology to enhance the sensitivity of nuclear magnetic resonance (NMR). The hyperpolarized (HP) chemical probe, which is a low molecular mass compound labeled with an NMR-positive nuclei like 13C or 15N, is dissolved in a glassing agent (e.g. glycerol/H2O) doped with a stable radical compound (OX063, etc.). The sample mixture is conditioned in a polarizing system (e.g. 3.35 Tesla, -271.6 °C, 2.8 mbar), and irradiation of the unpaired electrons with microwaves (e.g. 94 GHz, 100 mW) transfers the spin polarization from the electrons to the nuclei through the Overhauser effect. Using a superheated solvent (~200 °C), the polarized sample mixture is immediately dissolved by warming up to around biological temperature, and then quickly transferred for NMR/MRI acquisition. The chemical shift change of NMR-positive nuclei, which is induced upon the structural conversion of the HP chemical probe as a tracer, can be observed in real-time depending on the enhanced NMR signals over 4 orders of magnitude (>10,000-fold). Following the development of functional HP chemical probes and surrounding options, this technology is currently being applied to non-invasive NMR spectroscopy for direct monitoring of cell metabolism, MRI metabolic imaging of various disease animal models, and patients with cancer. 
  In this symposium, a brief overview of the HP-NMR/MRI will be presented, focusing on the application in radiation research as well as the current topics and future directions of this technology., 日本放射線影響学会第 62 回大会},
 title = {放射線研究における超偏極−核磁気共鳴分光法とイメージングの応用},
 year = {2019}
}