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Small-animal PET study: excess glutamate release upregulates mGluR1 availability
https://repo.qst.go.jp/records/77343
https://repo.qst.go.jp/records/773432295e342-ea9c-473b-9201-6b464145a67e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-07 | |||||
| タイトル | ||||||
| タイトル | Small-animal PET study: excess glutamate release upregulates mGluR1 availability | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
山崎, 友照
× 山崎, 友照× 岡田, 真希× 森, 若菜× 張, 一鼎× 脇坂, 秀克× 小川, 政直× 藤永, 雅之× 張, 明栄× Yamasaki, Tomoteru× Okada, Maki× Mori, Wakana× Zhang, Yiding× Wakizaka, Hidekatsu× Ogawa, Masanao× Fujinaga, Masayuki× Ming-Rong, Zhang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Metabotropic glutamate receptor subtype 1 (mGluR1) regulates glutamate (Glu) excitotoxicity in CNS. Here, we aimed to monitor mGluR1 in rat with excess Glu release. Method: The rat, which intraperitoneally transplanted an Alzet osmotic pump containing N-acetyl-L-cysteine (NAC) solution, was used for this study. Extracellular Glu concentrations (EGc) were measured by microdialysis. PET assessments with [11C]ITDM, a selective radioligand for mGluR1, were conducted at several time points after the transplantation. Results: EGc in the day 1 (D1) of both groups increased compared to the pre-experiments. Following, EGc of NAC subjects kept rising until the D7. Similarly, PET study with [11C]ITDM showed retaining BPND with high level in the D7 of NAC subjects compared to the control subjects. Conclusion: [11C]ITDM-BPND is upregulated depending on increase of EGc. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-02 | |||||
| 日付タイプ | Issued | |||||
