@misc{oai:repo.qst.go.jp:00077343,
 author = {山崎, 友照 and 岡田, 真希 and 森, 若菜 and 張, 一鼎 and 脇坂, 秀克 and 小川, 政直 and 藤永, 雅之 and 張, 明栄 and Yamasaki, Tomoteru and Okada, Maki and Mori, Wakana and Zhang, Yiding and Wakizaka, Hidekatsu and Ogawa, Masanao and Fujinaga, Masayuki and Ming-Rong, Zhang},
 month = {Nov},
 note = {Objective: Metabotropic glutamate receptor subtype 1 (mGluR1) regulates glutamate (Glu) excitotoxicity in CNS. Here, we aimed to monitor mGluR1 in rat with excess Glu release. 
Method: The rat, which intraperitoneally transplanted an Alzet osmotic pump containing N-acetyl-L-cysteine (NAC) solution, was used for this study. Extracellular Glu concentrations (EGc) were measured by microdialysis. PET assessments with [11C]ITDM, a selective radioligand for mGluR1, were conducted at several time points after the transplantation. 
Results: EGc in the day 1 (D1) of both groups increased compared to the pre-experiments. Following, EGc of NAC subjects kept rising until the D7. Similarly, PET study with [11C]ITDM showed retaining BPND with high level in the D7 of NAC subjects compared to the control subjects.
Conclusion: [11C]ITDM-BPND is upregulated depending on increase of EGc., 第59回日本核医学会学術総会},
 title = {Small-animal PET study: excess glutamate release upregulates mGluR1 availability},
 year = {2019}
}