{"created":"2023-05-15T14:56:59.655504+00:00","id":77343,"links":{},"metadata":{"_buckets":{"deposit":"4bf51012-ea09-4252-85d0-f75bce6553e8"},"_deposit":{"created_by":1,"id":"77343","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77343"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077343","sets":["10:29"]},"author_link":["799515","799504","799509","799506","799511","799512","799513","799516","799502","799514","799505","799503","799501","799507","799508","799510"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Metabotropic glutamate receptor subtype 1 (mGluR1) regulates glutamate (Glu) excitotoxicity in CNS. Here, we aimed to monitor mGluR1 in rat with excess Glu release. \nMethod: The rat, which intraperitoneally transplanted an Alzet osmotic pump containing N-acetyl-L-cysteine (NAC) solution, was used for this study. Extracellular Glu concentrations (EGc) were measured by microdialysis. PET assessments with [11C]ITDM, a selective radioligand for mGluR1, were conducted at several time points after the transplantation. \nResults: EGc in the day 1 (D1) of both groups increased compared to the pre-experiments. Following, EGc of NAC subjects kept rising until the D7. Similarly, PET study with [11C]ITDM showed retaining BPND with high level in the D7 of NAC subjects compared to the control subjects.\nConclusion: [11C]ITDM-BPND is upregulated depending on increase of EGc.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第59回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"799501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田, 真希"}],"nameIdentifiers":[{"nameIdentifier":"799502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"799503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"799504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"799505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"799506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"799507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"799508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Wakana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799516","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Small-animal PET study: excess glutamate release upregulates mGluR1 availability","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Small-animal PET study: excess glutamate release upregulates mGluR1 availability"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-07"},"publish_date":"2019-11-07","publish_status":"0","recid":"77343","relation_version_is_last":true,"title":["Small-animal PET study: excess glutamate release upregulates mGluR1 availability"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:42.988966+00:00"}