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Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observed by small-angle X-ray scattering
https://repo.qst.go.jp/records/77319
https://repo.qst.go.jp/records/77319bfd54fd3-e4f3-4916-91e5-9aed51a8100e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-12 | |||||
| タイトル | ||||||
| タイトル | Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observed by small-angle X-ray scattering | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsuo, Tatsuhito
× Matsuo, Tatsuhito× Fujiwara, Satoru× Matsuo, Tatsuhito× Fujiwara, Satoru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the structural changes of thin filaments caused by a cardiomyopathy-causing mutation E244D of troponin (Tn) T, small-angle X-ray scattering measurements were carried out on thin filaments containing the human cardiac wild-type Tn (WTF) and those containing the E244D mutant of Tn (DTF) in both the –Ca2+ and +Ca2+ states. Analysis by model calculation detected quaternary structural changes in both states. In particular, tropomyosin (Tm) of the DTF exposed more myosin-binding sites on actin than the WTF in the +Ca2+ state. Our results suggest that myosin binding is promoted by the E244D mutation, which leads to the increased force development as reported for this mutation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第57回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-24 | |||||
| 日付タイプ | Issued | |||||
