@misc{oai:repo.qst.go.jp:00077319,
 author = {Matsuo, Tatsuhito and Fujiwara, Satoru and Matsuo, Tatsuhito and Fujiwara, Satoru},
 month = {Sep},
 note = {To investigate the structural changes of thin filaments caused by a cardiomyopathy-causing mutation E244D of troponin (Tn) T, small-angle X-ray scattering measurements were carried out on thin filaments containing the human cardiac wild-type Tn (WTF) and those containing the E244D mutant of Tn (DTF) in both the –Ca2+ and +Ca2+ states. Analysis by model calculation detected quaternary structural changes in both states. In particular, tropomyosin (Tm) of the DTF exposed more myosin-binding sites on actin than the WTF in the +Ca2+ state. Our results suggest that myosin binding is promoted by the E244D mutation, which leads to the increased force development as reported for this mutation., 第57回日本生物物理学会年会},
 title = {Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observed by small-angle X-ray scattering},
 year = {2019}
}