{"created":"2023-05-15T14:56:58.541264+00:00","id":77319,"links":{},"metadata":{"_buckets":{"deposit":"f1c075f5-b541-42e4-b4d6-3726dfe208ba"},"_deposit":{"created_by":1,"id":"77319","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77319"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077319","sets":["10:28"]},"author_link":["825350","825351","825349","825352"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-09-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To investigate the structural changes of thin filaments caused by a cardiomyopathy-causing mutation E244D of troponin (Tn) T, small-angle X-ray scattering measurements were carried out on thin filaments containing the human cardiac wild-type Tn (WTF) and those containing the E244D mutant of Tn (DTF) in both the –Ca2+ and +Ca2+ states. Analysis by model calculation detected quaternary structural changes in both states. In particular, tropomyosin (Tm) of the DTF exposed more myosin-binding sites on actin than the WTF in the +Ca2+ state. Our results suggest that myosin binding is promoted by the E244D mutation, which leads to the increased force development as reported for this mutation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本生物物理学会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuo, Tatsuhito"}],"nameIdentifiers":[{"nameIdentifier":"825349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujiwara, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"825350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuo, Tatsuhito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"825351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujiwara, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"825352","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observed by small-angle X-ray scattering","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observed by small-angle X-ray scattering"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-12"},"publish_date":"2019-09-12","publish_status":"0","recid":"77319","relation_version_is_last":true,"title":["Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observed by small-angle X-ray scattering"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:11:12.499990+00:00"}