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Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells
https://repo.qst.go.jp/records/77053
https://repo.qst.go.jp/records/7705326a2b903-5578-433e-a8fc-1369438172bc
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-03 | |||||
| タイトル | ||||||
| タイトル | Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sai, Sei
× Sai, Sei× Suzuki, Masao× Vares, Guillaume× Horimoto, Yoshiya× 林, 光弘× Sai, Sei× Suzuki, Masao× Vares, Guillaume× Horimoto, Yoshiya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study, we attempt to investigate effects of carbon-ion beam alone, or in combination with lapatinib, a dual tyrosine kinase inhibitor, on targeting HER2-positive breast cancer stem-like cells (CSCs). Spheroid formation assays confirmed that ESA+/CD24- cells have CSC properties compared to ESA-/CD24+ cells in HER2-positive breast cancer cells. Carbon-ion beam combined with lapatinib significantly suppressed spheroid formation compared to X-rays combined with lapatinib or carbon ion beam alone. Carbon-ion beam combined with lapatinib greatly enhanced apoptosis and also induced autophagy-related expression of Beclin1 and LC3 compared to carbon-ion beam alone, X-rays alone, or X-rays combined with lapatinib. In addition, a large-sized gammaH2AX foci in CSCs were induced by carbon ion beam combined with lapatinib treatment in CSCs compared to cells receiving X-rays or carbon-ion beam alone. In conclusion, combination of carbon-ion beam irradiation and lapatinib has a high potential to kill HER2-positive breast CSCs, causing severe irreparable DNA damage, enhanced autophagy, and apoptosis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第78回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-26 | |||||
| 日付タイプ | Issued | |||||
