{"created":"2023-05-15T14:56:46.561081+00:00","id":77053,"links":{},"metadata":{"_buckets":{"deposit":"22f4d931-ec3b-4361-92a0-58636116030a"},"_deposit":{"created_by":1,"id":"77053","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77053"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077053","sets":["10:29"]},"author_link":["789768","789767","789770","789772","789771","789769","789765","789766","789764"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-09-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the present study, we attempt to investigate effects of carbon-ion beam alone, or in combination with lapatinib, a dual tyrosine kinase inhibitor, on targeting HER2-positive breast cancer stem-like cells (CSCs). Spheroid formation assays confirmed that ESA+/CD24- cells have CSC properties compared to ESA-/CD24+ cells in HER2-positive breast cancer cells. Carbon-ion beam combined with lapatinib significantly suppressed spheroid formation compared to X-rays combined with lapatinib or carbon ion beam alone. Carbon-ion beam combined with lapatinib greatly enhanced apoptosis and also induced autophagy-related expression of Beclin1 and LC3 compared to carbon-ion beam alone, X-rays alone, or X-rays combined with lapatinib. In addition, a large-sized gammaH2AX foci in CSCs were induced by carbon ion beam combined with lapatinib treatment in CSCs compared to cells receiving X-rays or carbon-ion beam alone. In conclusion, combination of carbon-ion beam irradiation and lapatinib has a high potential to kill HER2-positive breast CSCs, causing severe irreparable DNA damage, enhanced autophagy, and apoptosis.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第78回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"789764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"789765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"789766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Horimoto, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"789767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林, 光弘"}],"nameIdentifiers":[{"nameIdentifier":"789768","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Horimoto, Yoshiya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789772","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-03"},"publish_date":"2019-10-03","publish_status":"0","recid":"77053","relation_version_is_last":true,"title":["Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:03:53.638098+00:00"}