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Free energy profiles of unwrapping nucleosomal DNA under torsional stress and eviction of the H2A/H2B dimer
https://repo.qst.go.jp/records/77003
https://repo.qst.go.jp/records/77003d46f9935-491a-4d88-a850-29727faa5e86
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-08-29 | |||||
| タイトル | ||||||
| タイトル | Free energy profiles of unwrapping nucleosomal DNA under torsional stress and eviction of the H2A/H2B dimer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishida, Hisashi
× Ishida, Hisashi× Kono, Hidetoshi× Ishida, Hisashi× Kono, Hidetoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The structure and dynamics of chromatin is exposed to and affected by torsional stress in a nucleus. To understand how the torsional stress changes the stability of nucleosomes, we carried out all-atom molecular dynamics simulations to examine the unwrapping of the outer superhelical turn of the nucleosomal DNA from the histone octamer under the torsional stress imposed on the edges of the DNA. We found that the torsional stress can control the transitional path of symmetric and asymmetric unwrapping of the DNA by changing the interaction between the DNA and the histone core through conformational change in the DNA. We also show the free energy profile of eviction of the H2A/H2B dimer and conformational change of the histone core during the DNA unwrapping. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第57回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-26 | |||||
| 日付タイプ | Issued | |||||
