{"created":"2023-05-15T14:56:44.360586+00:00","id":77003,"links":{},"metadata":{"_buckets":{"deposit":"58b3b260-d2a6-4e71-af4f-eaa824f3ab3b"},"_deposit":{"created_by":1,"id":"77003","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77003"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077003","sets":["10:28"]},"author_link":["820704","820703","820705","820702"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-09-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The structure and dynamics of chromatin is exposed to and affected by torsional stress in a nucleus. To understand how the torsional stress changes the stability of nucleosomes, we carried out all-atom molecular dynamics simulations to examine the unwrapping of the outer superhelical turn of the nucleosomal DNA from the histone octamer under the torsional stress imposed on the edges of the DNA. We found that the torsional stress can control the transitional path of symmetric and asymmetric unwrapping of the DNA by changing the interaction between the DNA and the histone core through conformational change in the DNA. We also show the free energy profile of eviction of the H2A/H2B dimer and conformational change of the histone core during the DNA unwrapping.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回日本生物物理学会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishida, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"820702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"820703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishida, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"820704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Hidetoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"820705","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Free energy profiles of unwrapping nucleosomal DNA under torsional stress and eviction of the H2A/H2B dimer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Free energy profiles of unwrapping nucleosomal DNA under torsional stress and eviction of the H2A/H2B dimer"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-29"},"publish_date":"2019-08-29","publish_status":"0","recid":"77003","relation_version_is_last":true,"title":["Free energy profiles of unwrapping nucleosomal DNA under torsional stress and eviction of the H2A/H2B dimer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:18:19.409988+00:00"}