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Radiation-induced, tumor-infiltrating neutrophils play an important role in the therapeutic effect
https://repo.qst.go.jp/records/76998
https://repo.qst.go.jp/records/7699889638fb7-4e29-441c-95ec-490c94ecd413
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-30 | |||||
| タイトル | ||||||
| タイトル | Radiation-induced, tumor-infiltrating neutrophils play an important role in the therapeutic effect | |||||
| タイトル | ||||||
| タイトル | 放射線治療後に腫瘍内に浸潤する好中球は抗腫瘍作用を示す | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takeshima, Tsuguhide
× Takeshima, Tsuguhide× nakako, nakajima× Shimokawa, Takashi× Hasegawa, Sumitaka× Takeshima, Tsuguhide× Nakajima, Nakako× Shimokawa, Takashi× Hasegawa, Sumitaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation therapy (RT) is one of the primary treatment modalities for many cancers. In the present study using the RM-9 (mouse prostate tumor cell line)-bearing C57BL/6 mice or to the 4T1(mouse mammary cell line)-bearing BALB/c mice, we demonstrated that RT induces sterile inflammation with an infiltration of CD11b<SUP>+</SUP>Gr-1<SUP>+</SUP> neutrophils reached a peak within the tumor microenvironment at 24-48 h after tumor RT. RT-recruited neutrophils (RT-Ns) exhibit an increased production of reactive oxygen species (ROS) and induce apoptosis of tumor cells. The anti-tumor activity of RT is significantly reduced when RT-Ns are depleted with an anti-Ly-6G antibody (1A8), resulting in decreased apoptosis of tumor cells. In contrast, treatment with G-CSF, known to activate neutrophils, elevates ROS production by RT-Ns. This leads to enhanced tumor cytotoxicity followed by an increased tumor-specific CD8<SUP>+</SUP> T cell response. These results suggest that RT given in conjunction with G-CSF may be an effective strategy for improving the anti-tumor activity of RT. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第78回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-27 | |||||
| 日付タイプ | Issued | |||||
