@misc{oai:repo.qst.go.jp:00076998,
 author = {Takeshima, Tsuguhide and nakako, nakajima and Shimokawa, Takashi and Hasegawa, Sumitaka and Takeshima, Tsuguhide and Nakajima, Nakako and Shimokawa, Takashi and Hasegawa, Sumitaka},
 month = {Sep},
 note = {Radiation therapy (RT) is one of the primary treatment modalities for many cancers. In the present study using the RM-9 (mouse prostate tumor cell line)-bearing C57BL/6 mice or to the 4T1(mouse mammary cell line)-bearing BALB/c mice, we demonstrated that RT induces sterile inflammation with an infiltration of CD11b<SUP>+</SUP>Gr-1<SUP>+</SUP> neutrophils reached a peak within the tumor microenvironment at 24-48 h after tumor RT. RT-recruited neutrophils (RT-Ns) exhibit an increased production of reactive oxygen species (ROS) and induce apoptosis of tumor cells. The anti-tumor activity of RT is significantly reduced when RT-Ns are depleted with an anti-Ly-6G antibody (1A8), resulting in decreased apoptosis of tumor cells. In contrast, treatment with G-CSF, known to activate neutrophils, elevates ROS production by RT-Ns. This leads to enhanced tumor cytotoxicity followed by an increased tumor-specific CD8<SUP>+</SUP> T cell response. These results suggest that RT given in conjunction with G-CSF may be an effective strategy for improving the anti-tumor activity of RT., 第78回日本癌学会学術総会},
 title = {Radiation-induced, tumor-infiltrating neutrophils play an important role in the therapeutic effect},
 year = {2019}
}