{"created":"2023-05-15T14:56:44.137687+00:00","id":76998,"links":{},"metadata":{"_buckets":{"deposit":"fa398ab3-d053-4dc3-ba47-043cf563bdbb"},"_deposit":{"created_by":1,"id":"76998","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76998"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076998","sets":["10:29"]},"author_link":["789714","789716","789715","789712","789713","789709","789710","789711"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-09-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiation therapy (RT) is one of the primary treatment modalities for many cancers. In the present study using the RM-9 (mouse prostate tumor cell line)-bearing C57BL/6 mice or to the 4T1(mouse mammary cell line)-bearing BALB/c mice, we demonstrated that RT induces sterile inflammation with an infiltration of CD11b<SUP>+</SUP>Gr-1<SUP>+</SUP> neutrophils reached a peak within the tumor microenvironment at 24-48 h after tumor RT. RT-recruited neutrophils (RT-Ns) exhibit an increased production of reactive oxygen species (ROS) and induce apoptosis of tumor cells. The anti-tumor activity of RT is significantly reduced when RT-Ns are depleted with an anti-Ly-6G antibody (1A8), resulting in decreased apoptosis of tumor cells. In contrast, treatment with G-CSF, known to activate neutrophils, elevates ROS production by RT-Ns. This leads to enhanced tumor cytotoxicity followed by an increased tumor-specific CD8<SUP>+</SUP> T cell response. These results suggest that RT given in conjunction with G-CSF may be an effective strategy for improving the anti-tumor activity of RT. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第78回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeshima, Tsuguhide"}],"nameIdentifiers":[{"nameIdentifier":"789709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"nakako, nakajima"}],"nameIdentifiers":[{"nameIdentifier":"789710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"789711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka"}],"nameIdentifiers":[{"nameIdentifier":"789712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeshima, Tsuguhide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Nakako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"789716","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radiation-induced, tumor-infiltrating neutrophils play an important role in the therapeutic effect","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation-induced, tumor-infiltrating neutrophils play an important role in the therapeutic effect"},{"subitem_title":"放射線治療後に腫瘍内に浸潤する好中球は抗腫瘍作用を示す","subitem_title_language":"en"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-30"},"publish_date":"2019-09-30","publish_status":"0","recid":"76998","relation_version_is_last":true,"title":["Radiation-induced, tumor-infiltrating neutrophils play an important role in the therapeutic effect"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:04:00.187333+00:00"}