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FRET study on sequence-dependent unwrapping of nucleosomal DNA
https://repo.qst.go.jp/records/76954
https://repo.qst.go.jp/records/769540ad94905-c789-4409-a014-cc289f3d49c1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-03 | |||||
| タイトル | ||||||
| タイトル | FRET study on sequence-dependent unwrapping of nucleosomal DNA | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
角南, 智子
× 角南, 智子× ルオ, ディ× 河野, 秀俊× Sunami, Tomoko× Luo, Di× Kono, Hidetoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The first nucleosomes in the downstream of the transcription starting sites, +1 nucleosomes, have been found to play critical roles in genome organization. We have previously proposed that consecutive AA/TT dimer sequences in the entry side of +1 nucleosomes tend to unwrap more easily than those without AA/TT (Luo et al, NAR, 2018). To reveal sequence-dependent unwrapping in more detail, we conducted FRET measurement of reconstituted nucleosomes with sequences containing AA/TT repeat or containing the other dimer repeats. Our time-correlated single photon counting analysis showed that (1) the open state population is the most abundant in the nucleosomes with AT-rich sequences and (2) the open state is the most widely opened on the nucleosomes with long AA/TT repeat. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第57回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-09-25 | |||||
| 日付タイプ | Issued | |||||
