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アイテム
LET Dependent Generations of Reactive Oxygen Species and RedOx Reactions in an Aqueous Sample Irradiated by X-ray or Carbon-Ion Beam
https://repo.qst.go.jp/records/75030
https://repo.qst.go.jp/records/7503022fc4ef9-1f26-4b58-8eb4-108e20deb454
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-16 | |||||
| タイトル | ||||||
| タイトル | LET Dependent Generations of Reactive Oxygen Species and RedOx Reactions in an Aqueous Sample Irradiated by X-ray or Carbon-Ion Beam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Nyui, Minako× Ueno, Megumi× Ogawa, Yukihiro× Nakanishi, Ikuo× Matsumoto, Kenichiro× Nyui, Minako× Ueno, Megumi× Ogawa, Yukihiro× Nakanishi, Ikuo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hydroxyl radicals (*OH), hydrogen peroxide (H{sub}2{/sub}O{sub}2{/sub}), and superoxide (O{sub}2{/sub}{sup}*-{/sup}) are the important reactive oxygen species (ROS) for considering radio-biological effects. ROS generations in aqueous samples by X-ray or carbon-ion beams were quantified. Amount and distribution of *OH, H{sub}2{/sub}O{sub}2{/sub}, and total oxidation reactions were estimated by an electron paramagnetic resonance (EPR) spin-trapping, a modified spin-trapping, and spin-probing method, respectively. *OH generation was expected to be localized on the track/range of the radiation, and mM and M levels of *OH generation were observed. Total *OH generation was expected to be identical at the same dose even for X-ray or carbon-ion beam. Sparse *OH generation decreased with increasing LET. Carbon-ion beam produced denser H{sub}2{/sub}O{sub}2{/sub} compared with X-ray irradiation. H{sub}2{/sub}O{sub}2{/sub} generation decreased with the LET increasing, although the ratio of H{sub}2{/sub}O{sub}2{/sub} generation per oxygen consumed increased with LET. Total oxidation reactions decreased with increasing LET. Total oxidation reactions caused by low LET conditions decreased when the experiment was performed at low O{sub}2{/sub} concentration, while no difference was observed by high LET conditions. ROS generation was not uniform and was LET dependent at the molecular level. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 9th Biennial Meeting for the Society for Free Radical Research Asia | |||||
| 発表年月日 | ||||||
| 日付 | 2019-04-06 | |||||
| 日付タイプ | Issued | |||||
