@misc{oai:repo.qst.go.jp:00075030,
 author = {Ken-ichiro, Matsumoto and Nyui, Minako and Ueno, Megumi and Ogawa, Yukihiro and Nakanishi, Ikuo and Matsumoto, Kenichiro and Nyui, Minako and Ueno, Megumi and Ogawa, Yukihiro and Nakanishi, Ikuo},
 month = {Apr},
 note = {Hydroxyl radicals (*OH), hydrogen peroxide (H{sub}2{/sub}O{sub}2{/sub}), and superoxide (O{sub}2{/sub}{sup}*-{/sup}) are the important reactive oxygen species (ROS) for considering radio-biological effects. ROS generations in aqueous samples by X-ray or carbon-ion beams were quantified.
Amount and distribution of *OH, H{sub}2{/sub}O{sub}2{/sub}, and total oxidation reactions were estimated by an electron paramagnetic resonance (EPR) spin-trapping, a modified spin-trapping, and spin-probing method, respectively.
*OH generation was expected to be localized on the track/range of the radiation, and mM and M levels of *OH generation were observed. Total *OH generation was expected to be identical at the same dose even for X-ray or carbon-ion beam. Sparse *OH generation decreased with increasing LET. Carbon-ion beam produced denser H{sub}2{/sub}O{sub}2{/sub} compared with X-ray irradiation. H{sub}2{/sub}O{sub}2{/sub} generation decreased with the LET increasing, although the ratio of H{sub}2{/sub}O{sub}2{/sub} generation per oxygen consumed increased with LET. Total oxidation reactions decreased with increasing LET. Total oxidation reactions caused by low LET conditions decreased when the experiment was performed at low O{sub}2{/sub} concentration, while no difference was observed by high LET conditions.
ROS generation was not uniform and was LET dependent at the molecular level., 9th Biennial Meeting for the Society for Free Radical Research Asia},
 title = {LET Dependent Generations of Reactive Oxygen Species and RedOx Reactions in an Aqueous Sample Irradiated by X-ray or Carbon-Ion Beam},
 year = {2019}
}