{"_buckets": {"deposit": "6af394d5-e4bc-4ce4-bcc7-9477b37a75cb"}, "_deposit": {"created_by": 1, "id": "74693", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "74693"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00074693", "sets": ["28"]}, "author_link": ["736034", "736038", "736041", "736042", "736029", "736035", "736037", "736031", "736033", "736040", "736030", "736036", "736039", "736032"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2018-11-16", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Sequencing empowers clinical diagnostics and therapy, but targeted alpha therapy has not yet fully received it. Recently, we observed strong anti-tumor effect of 211At-MABG in a pheochromocytoma mouse model. Here, we used RNA-sequencing to identify genes relevant to induced anti-tumor alpha-particle radiation response compared with 60Co γ-rays. The gene expression changes of PC12 cells were observed at 3, 6 and 12 h after 211At-MABG treatment and 60Co γ-rays irradiation, controlling dose of irradiation at survival levels of 10% and 80%. Minimum of 7 million reads were sequenced for each condition. Overall transcriptome profiles were strikingly distinct, but important gene expression changes of 10% survival for cell-cycle checkpoints finally reached the same level with a time delay. We now explore possible therapy or molecular imaging target genes for malignant pheochromocytoma.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "第58回日本核医学会学術総会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "坂下, 哲哉"}], "nameIdentifiers": [{"nameIdentifier": "736029", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大島, 康宏"}], "nameIdentifiers": [{"nameIdentifier": "736030", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "河野, 暢明"}], "nameIdentifiers": [{"nameIdentifier": "736031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "横田, 裕一郎"}], "nameIdentifiers": [{"nameIdentifier": "736032", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "渡辺, 茂樹"}], "nameIdentifiers": [{"nameIdentifier": "736033", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐々木, 一郎"}], "nameIdentifiers": [{"nameIdentifier": "736034", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "石岡, 典子"}], "nameIdentifiers": [{"nameIdentifier": "736035", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "荒川, 和晴"}], "nameIdentifiers": [{"nameIdentifier": "736036", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakashita, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "736037", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshima, Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "736038", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokota, Yuuichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "736039", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Shigeki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "736040", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Ichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "736041", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishioka, Noriko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "736042", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/74693", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-03-11"}, "publish_date": "2019-03-11", "publish_status": "0", "recid": "74693", "relation": {}, "relation_version_is_last": true, "title": ["RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells"], "weko_shared_id": -1}