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  1. 学会発表・講演等
  2. ポスター発表

RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells

https://repo.qst.go.jp/records/74693
https://repo.qst.go.jp/records/74693
74a448aa-eec4-409d-8038-9d88a4ab99a8
Item type 会議発表用資料 / Presentation(1)
公開日 2019-03-11
タイトル
タイトル RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 坂下, 哲哉

× 坂下, 哲哉

WEKO 736029

坂下, 哲哉

Search repository
大島, 康宏

× 大島, 康宏

WEKO 736030

大島, 康宏

Search repository
河野, 暢明

× 河野, 暢明

WEKO 736031

河野, 暢明

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横田, 裕一郎

× 横田, 裕一郎

WEKO 736032

横田, 裕一郎

Search repository
渡辺, 茂樹

× 渡辺, 茂樹

WEKO 736033

渡辺, 茂樹

Search repository
佐々木, 一郎

× 佐々木, 一郎

WEKO 736034

佐々木, 一郎

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石岡, 典子

× 石岡, 典子

WEKO 736035

石岡, 典子

Search repository
荒川, 和晴

× 荒川, 和晴

WEKO 736036

荒川, 和晴

Search repository
Sakashita, Tetsuya

× Sakashita, Tetsuya

WEKO 736037

en Sakashita, Tetsuya

Search repository
Oshima, Yasuhiro

× Oshima, Yasuhiro

WEKO 736038

en Oshima, Yasuhiro

Search repository
Yokota, Yuuichiro

× Yokota, Yuuichiro

WEKO 736039

en Yokota, Yuuichiro

Search repository
Watanabe, Shigeki

× Watanabe, Shigeki

WEKO 736040

en Watanabe, Shigeki

Search repository
Sasaki, Ichiro

× Sasaki, Ichiro

WEKO 736041

en Sasaki, Ichiro

Search repository
Ishioka, Noriko

× Ishioka, Noriko

WEKO 736042

en Ishioka, Noriko

Search repository
抄録
内容記述タイプ Abstract
内容記述 Sequencing empowers clinical diagnostics and therapy, but targeted alpha therapy has not yet fully received it. Recently, we observed strong anti-tumor effect of 211At-MABG in a pheochromocytoma mouse model. Here, we used RNA-sequencing to identify genes relevant to induced anti-tumor alpha-particle radiation response compared with 60Co γ-rays. The gene expression changes of PC12 cells were observed at 3, 6 and 12 h after 211At-MABG treatment and 60Co γ-rays irradiation, controlling dose of irradiation at survival levels of 10% and 80%. Minimum of 7 million reads were sequenced for each condition. Overall transcriptome profiles were strikingly distinct, but important gene expression changes of 10% survival for cell-cycle checkpoints finally reached the same level with a time delay. We now explore possible therapy or molecular imaging target genes for malignant pheochromocytoma.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 第58回日本核医学会学術総会
発表年月日
日付 2018-11-16
日付タイプ Issued
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