{"created":"2023-05-15T14:54:57.793541+00:00","id":74693,"links":{},"metadata":{"_buckets":{"deposit":"6af394d5-e4bc-4ce4-bcc7-9477b37a75cb"},"_deposit":{"created_by":1,"id":"74693","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"74693"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00074693","sets":["10:28"]},"author_link":["736034","736038","736041","736042","736029","736035","736037","736031","736033","736040","736030","736036","736039","736032"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sequencing empowers clinical diagnostics and therapy, but targeted alpha therapy has not yet fully received it. Recently, we observed strong anti-tumor effect of 211At-MABG in a pheochromocytoma mouse model. Here, we used RNA-sequencing to identify genes relevant to induced anti-tumor alpha-particle radiation response compared with 60Co γ-rays. The gene expression changes of PC12 cells were observed at 3, 6 and 12 h after 211At-MABG treatment and 60Co γ-rays irradiation, controlling dose of irradiation at survival levels of 10% and 80%. Minimum of 7 million reads were sequenced for each condition. Overall transcriptome profiles were strikingly distinct, but important gene expression changes of 10% survival for cell-cycle checkpoints finally reached the same level with a time delay. We now explore possible therapy or molecular imaging target genes for malignant pheochromocytoma.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第58回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂下, 哲哉"}],"nameIdentifiers":[{"nameIdentifier":"736029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 康宏"}],"nameIdentifiers":[{"nameIdentifier":"736030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河野, 暢明"}],"nameIdentifiers":[{"nameIdentifier":"736031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横田, 裕一郎"}],"nameIdentifiers":[{"nameIdentifier":"736032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺, 茂樹"}],"nameIdentifiers":[{"nameIdentifier":"736033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 一郎"}],"nameIdentifiers":[{"nameIdentifier":"736034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡, 典子"}],"nameIdentifiers":[{"nameIdentifier":"736035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川, 和晴"}],"nameIdentifiers":[{"nameIdentifier":"736036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakashita, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"736037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"736038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokota, Yuuichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"736039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"736040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"736041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"736042","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-11"},"publish_date":"2019-03-11","publish_status":"0","recid":"74693","relation_version_is_last":true,"title":["RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T07:51:07.226466+00:00"}