@misc{oai:repo.qst.go.jp:00074693,
 author = {坂下, 哲哉 and 大島, 康宏 and 河野, 暢明 and 横田, 裕一郎 and 渡辺, 茂樹 and 佐々木, 一郎 and 石岡, 典子 and 荒川, 和晴 and Sakashita, Tetsuya and Oshima, Yasuhiro and Yokota, Yuuichiro and Watanabe, Shigeki and Sasaki, Ichiro and Ishioka, Noriko},
 month = {Nov},
 note = {Sequencing empowers clinical diagnostics and therapy, but targeted alpha therapy has not yet fully received it. Recently, we observed strong anti-tumor effect of 211At-MABG in a pheochromocytoma mouse model. Here, we used RNA-sequencing to identify genes relevant to induced anti-tumor alpha-particle radiation response compared with 60Co γ-rays. The gene expression changes of PC12 cells were observed at 3, 6 and 12 h after 211At-MABG treatment and 60Co γ-rays irradiation, controlling dose of irradiation at survival levels of 10% and 80%. Minimum of 7 million reads were sequenced for each condition. Overall transcriptome profiles were strikingly distinct, but important gene expression changes of 10% survival for cell-cycle checkpoints finally reached the same level with a time delay. We now explore possible therapy or molecular imaging target genes for malignant pheochromocytoma., 第58回日本核医学会学術総会},
 title = {RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells},
 year = {2018}
}