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Role of HIF-1α in the response of HNSCC cancer stem cells after carbon ion exposures
https://repo.qst.go.jp/records/72291
https://repo.qst.go.jp/records/72291274d6fd0-0a88-42ca-959c-430b75890016
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-21 | |||||
| タイトル | ||||||
| タイトル | Role of HIF-1α in the response of HNSCC cancer stem cells after carbon ion exposures | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wozny, A-S.
× Wozny, A-S.× Gersende, ALPHONSE× Vares, G.× 藤森, 亮× 中島, 徹夫× Rodriguez-Lafrasse, C.× 藤森 亮× 中島 徹夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to the presence of Cancer Stem Cells (CSCs) localized in hypoxic niches. The protein HIF-1α (Hypoxia-Inducible Factor 1α）is considered as the major transcriptional regulator of the cellular response to oxygen homeostasis. We previously showed that inhibition of HIF-1α lead to the decrease of HNSCC-CSC survival after carbon ion (GANIL, France (75MeV/n)) and photon irradiations in hypoxic conditions. This proposal aimed of clarifying the role of HIF-1α in the response of HNSCC-CSCs. After inhibition of HIF-１α with a siRNA, DNA repair and epithelio-mesenchymal transition(EMT) were studied in response to carbon ion(290MeV/n-SOBP) and photon (250kV) irradiations in normoxic or hypoxic(1% O2) conditions. Radiosentization observed after HIF-1αinhibition is associated with a significant increase of residual DSBs in response to both types of radiation. Furthermore, under hypoxia, HIF-1αinhibition is associated with a low proportion of migrating and invasive cells, confirming the role of HIF-1α in EMT. In summary,HIF-1α participates to radioresistance by increasing cell survival, DNA repair and invasiveness and contributes to tumor escape. These preliminary results will be confirmed during the next beam time. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H28年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-04-17 | |||||
| 日付タイプ | Issued | |||||
