{"created":"2023-05-15T14:52:58.197425+00:00","id":72291,"links":{},"metadata":{"_buckets":{"deposit":"9bf4230b-24d7-4fd4-adde-f291d9ee183e"},"_deposit":{"created_by":1,"id":"72291","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72291"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072291","sets":["10:28"]},"author_link":["712026","712025","712028","712023","712021","712022","712024","712027"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-04-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to the presence of Cancer Stem Cells (CSCs) localized in  hypoxic niches. The protein HIF-1α (Hypoxia-Inducible Factor 1α）is considered as the major transcriptional regulator of the cellular response to oxygen homeostasis. We previously showed that inhibition of HIF-1α lead to the decrease of HNSCC-CSC survival after carbon ion (GANIL, France (75MeV/n)) and photon irradiations in hypoxic conditions. This proposal aimed of clarifying the role of HIF-1α in the response of HNSCC-CSCs. After inhibition of HIF-１α with a siRNA, DNA repair and epithelio-mesenchymal transition(EMT) were studied in response to carbon ion(290MeV/n-SOBP) and photon (250kV) irradiations in normoxic or hypoxic(1% O2) conditions. Radiosentization observed after HIF-1αinhibition is associated with a significant increase of residual DSBs in response to both types of radiation. Furthermore, under hypoxia, HIF-1αinhibition is associated with a low proportion of migrating and invasive cells, confirming the role of HIF-1α in EMT. In summary,HIF-1α participates to radioresistance by increasing cell survival, DNA repair and invasiveness and contributes to tumor escape. These preliminary results will be confirmed during the next beam time.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"H28年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wozny, A-S."}],"nameIdentifiers":[{"nameIdentifier":"712021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gersende, ALPHONSE"}],"nameIdentifiers":[{"nameIdentifier":"712022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, G."}],"nameIdentifiers":[{"nameIdentifier":"712023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森, 亮"}],"nameIdentifiers":[{"nameIdentifier":"712024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"712025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rodriguez-Lafrasse, C."}],"nameIdentifiers":[{"nameIdentifier":"712026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712028","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Role of HIF-1α in the response of HNSCC cancer stem cells after carbon ion exposures","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of HIF-1α in the response of HNSCC cancer stem cells after carbon ion exposures"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-21"},"publish_date":"2017-04-21","publish_status":"0","recid":"72291","relation_version_is_last":true,"title":["Role of HIF-1α in the response of HNSCC cancer stem cells after carbon ion exposures"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:41:35.033042+00:00"}