WEKO3
アイテム
Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays
https://repo.qst.go.jp/records/71685
https://repo.qst.go.jp/records/7168516404d37-3f0b-4bc4-8ee4-5f3b927a195b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-06-02 | |||||
| タイトル | ||||||
| タイトル | Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
藤森, 亮
× 藤森, 亮× 高橋, 桃子× 平川, 博一× 矢島, 浩彦× 中島, 菜花子× 藤森 亮× 高橋 桃子× 平川 博一× 矢島 浩彦× 中島 菜花子 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this paper is to obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these cells with X-rays and carbon beam. Human monolayer-type A172 glioblastoma cells were maintained in normal medium with 10% bovine serum. In order to obtain sphere-type A172 cells the medium was replaced with serum-free medium supplemented with growth factors. Both types of A172 cells were irradiated with either X-rays or carbon ion beams and their radiosensitivity was evaluated. Serum-free medium induced expression of stem cell-related proteins in A172 cells along with the neurosphere-like appearance. These sphere-type cells were found resistant to both X-rays and carbon ion beams. Phosphorylation of histone H2A family member X persisted for a longer period in the cells exposed to carbon ion beams than in those exposed to X-rays and it disappeared quicker in the sphere type than in the monolayer type. Relative radioresistance of the sphere type cells was smaller for carbon ion beams than for X-rays. We demonstrated that glioblastoma A172 cells with induced stem cell-related proteins turned resistant to irradiation. Accelerated heavy ion particles may have advantage over X-rays in overcoming the tumor resistance due to cell stemness. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ICRR2015 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-05-27 | |||||
| 日付タイプ | Issued | |||||
