{"created":"2023-05-15T14:52:30.294371+00:00","id":71685,"links":{},"metadata":{"_buckets":{"deposit":"e44d7860-e21c-46ca-83fd-a96fceb02c95"},"_deposit":{"created_by":1,"id":"71685","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71685"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071685","sets":["10:28"]},"author_link":["705354","705358","705356","705350","705357","705352","705351","705355","705353","705359"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this paper is to obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these cells with X-rays and carbon beam. Human monolayer-type A172 glioblastoma cells were maintained in normal medium with 10% bovine serum. In order to obtain sphere-type A172 cells the medium was replaced with serum-free medium supplemented with growth factors. Both types of A172 cells were irradiated with either X-rays or carbon ion beams and their radiosensitivity was evaluated. Serum-free medium induced expression of stem cell-related proteins in A172 cells along with the neurosphere-like appearance. These sphere-type cells were found resistant to both X-rays and carbon ion beams. Phosphorylation of histone H2A family member X persisted for a longer period in the cells exposed to carbon ion beams than in those exposed to X-rays and it disappeared quicker in the sphere type than in the monolayer type. Relative radioresistance of the sphere type cells was smaller for carbon ion beams than for X-rays. We demonstrated that glioblastoma A172 cells with induced stem cell-related proteins turned resistant to irradiation. Accelerated heavy ion particles may have advantage over X-rays in overcoming the tumor resistance due to cell stemness.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ICRR2015","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤森, 亮"}],"nameIdentifiers":[{"nameIdentifier":"705350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 桃子"}],"nameIdentifiers":[{"nameIdentifier":"705351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平川, 博一"}],"nameIdentifiers":[{"nameIdentifier":"705352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢島, 浩彦"}],"nameIdentifiers":[{"nameIdentifier":"705353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 菜花子"}],"nameIdentifiers":[{"nameIdentifier":"705354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 桃子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平川 博一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢島 浩彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 菜花子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705359","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-02"},"publish_date":"2015-06-02","publish_status":"0","recid":"71685","relation_version_is_last":true,"title":["Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:48:31.534938+00:00"}