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アイテム
ARTEMIS欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強
https://repo.qst.go.jp/records/71649
https://repo.qst.go.jp/records/71649739289d3-e81c-4cb1-9f0c-08c36ab246b5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-05-13 | |||||
| タイトル | ||||||
| タイトル | ARTEMIS欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 上條, 岳彦× 白井, 敏之× 崔 星× 上條 岳彦× 白井 敏之 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Deficiency for ARTEMIS has been shown to be associated with multi-tissue tumor formation. Here we report the role of ARTEMIS in cancer stem cell (CSC) properties and radiosensitivity to X-ray and carbon ion beam. FACS analysis showed that the CSCs (CD133+, CD44+/ESA+) were significantly altered in ARTEMIS KO cells compared to HCT116-WT cells. The number of colony and spheroid formed from CSCs were significantly higher compared to that from non-CSCs in ARTEMIS KO cells, but remarkably decreased compared to that from HCT116-WT cells. The proportion of CSCs was more significantly increased in ARTEMIS KO cells compared to HCT116-WT cells after X-ray irradiation. Survival fraction analysis showed that the CSCs sorted from ARTEMIS-KO significantly radiosensitized compared to that of CSCs from HCT116-WT cells for both X-ray and carbon ion beam. In conclusion, lack of ARTEMIS significantly altered expression of CSC markers, radiosensitized CSCs to both X-ray and carbon ion beam, suggesting that ARTEMIS may be involved in modulating CSC properties. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第73回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-09-25 | |||||
| 日付タイプ | Issued | |||||
