{"created":"2023-05-15T14:52:28.661904+00:00","id":71649,"links":{},"metadata":{"_buckets":{"deposit":"2e6d569a-a55d-4574-9bcf-b7feb95c9141"},"_deposit":{"created_by":1,"id":"71649","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71649"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071649","sets":["10:28"]},"author_link":["704974","704975","704978","704976","704973","704977"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-09-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deficiency for ARTEMIS has been shown to be associated with multi-tissue tumor formation. Here we report the role of ARTEMIS in cancer stem cell (CSC) properties and radiosensitivity to X-ray and carbon ion beam. FACS analysis showed that the CSCs (CD133+, CD44+/ESA+) were significantly altered in ARTEMIS KO cells compared to HCT116-WT cells. The number of colony and spheroid formed from CSCs were significantly higher compared to that from non-CSCs in ARTEMIS KO cells, but remarkably decreased compared to that from HCT116-WT cells. The proportion of CSCs was more significantly increased in ARTEMIS  KO cells compared to HCT116-WT cells after X-ray irradiation. Survival fraction analysis showed that the CSCs sorted from ARTEMIS-KO significantly radiosensitized compared to that of CSCs from HCT116-WT cells for both X-ray and carbon ion beam. In conclusion, lack of ARTEMIS significantly altered expression of CSC markers, radiosensitized CSCs to both X-ray and carbon ion beam, suggesting that ARTEMIS may be involved in modulating CSC properties.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第73回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"崔, 星"}],"nameIdentifiers":[{"nameIdentifier":"704973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上條, 岳彦"}],"nameIdentifiers":[{"nameIdentifier":"704974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白井, 敏之"}],"nameIdentifiers":[{"nameIdentifier":"704975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上條 岳彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白井 敏之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704978","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ARTEMIS欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ARTEMIS欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-13"},"publish_date":"2015-05-13","publish_status":"0","recid":"71649","relation_version_is_last":true,"title":["ARTEMIS欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:48:54.493736+00:00"}