@misc{oai:repo.qst.go.jp:00071649,
 author = {崔, 星 and 上條, 岳彦 and 白井, 敏之 and 崔 星 and 上條 岳彦 and 白井 敏之},
 month = {Sep},
 note = {Deficiency for ARTEMIS has been shown to be associated with multi-tissue tumor formation. Here we report the role of ARTEMIS in cancer stem cell (CSC) properties and radiosensitivity to X-ray and carbon ion beam. FACS analysis showed that the CSCs (CD133+, CD44+/ESA+) were significantly altered in ARTEMIS KO cells compared to HCT116-WT cells. The number of colony and spheroid formed from CSCs were significantly higher compared to that from non-CSCs in ARTEMIS KO cells, but remarkably decreased compared to that from HCT116-WT cells. The proportion of CSCs was more significantly increased in ARTEMIS  KO cells compared to HCT116-WT cells after X-ray irradiation. Survival fraction analysis showed that the CSCs sorted from ARTEMIS-KO significantly radiosensitized compared to that of CSCs from HCT116-WT cells for both X-ray and carbon ion beam. In conclusion, lack of ARTEMIS significantly altered expression of CSC markers, radiosensitized CSCs to both X-ray and carbon ion beam, suggesting that ARTEMIS may be involved in modulating CSC properties., 第73回日本癌学会学術総会},
 title = {ARTEMIS欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強},
 year = {2014}
}