{"_buckets": {"deposit": "312d4a4e-2953-45f2-b692-64234b9ca8e7"}, "_deposit": {"created_by": 1, "id": "71632", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "71632"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00071632", "sets": ["28"]}, "author_link": ["704788", "704778", "704784", "704779", "704791", "704777", "704786", "704782", "704775", "704789", "704793", "704783", "704776", "704781", "704785", "704787", "704774", "704780", "704790", "704792"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2014-12-01", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【目的】我々はPET用タウイメージング剤である[11C]PBB3を開発した。[11C]PBB3 PETにて進行性核上性麻痺(PSP)および大脳基底核変性症(CBS)におけるタウ蛋白の脳内蓄積を検出できるかどうかを検討する。【対象および方法】対象はPSP11例(69±8歳)、CBS9例(68±7歳)、健常高齢者21例（67±6歳）である。これらの被験者に研究内容を説明し文書にて同意を得た。[11C]PBB3を約12mCi静脈投与し、Siemens HR+スキャナーにて70分間経時的脳内放射能を測定した。同日に[11C]PIB PETを行った。[11C]PBB3投与30-50分後のPET画像をMRI T1画像を用いて解剖学的標準化し、小脳皮質を参照領域としてSUVR画像を作成した。SPM8で3群間においてANOVA解析した。【結果】PIB陽性の健常者2例、CBS2例をSPM解析の対象から除外した。PSP群では中脳、淡蒼球、視床、視床下部、前頭から頭頂皮質に健常群と比較してPBB3の集積がみられた（p \u003c 0.01(unc), extent thresh hold \u003e 50）。CBS群では健常群と比較して前頭から頭頂皮質に高い集積がみられ、その集積はPSP群よりも高い傾向がみられた。【結論】[11C]PBB3 PETにて非アルツハイマー病タオオパシーのタウ病変を捉えることができる。", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "第33回日本認知症学会学術大会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "篠遠, 仁"}], "nameIdentifiers": [{"nameIdentifier": "704774", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田, 斉"}], "nameIdentifiers": [{"nameIdentifier": "704775", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平野, 成樹"}], "nameIdentifiers": [{"nameIdentifier": "704776", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古川, 彰吾"}], "nameIdentifiers": [{"nameIdentifier": "704777", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畑, 圭輔"}], "nameIdentifiers": [{"nameIdentifier": "704778", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村, 泰之"}], "nameIdentifiers": [{"nameIdentifier": "704779", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 真希子"}], "nameIdentifiers": [{"nameIdentifier": "704780", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤, 浩"}], "nameIdentifiers": [{"nameIdentifier": "704781", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口, 真人"}], 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