{"created":"2023-05-15T14:52:27.906601+00:00","id":71632,"links":{},"metadata":{"_buckets":{"deposit":"312d4a4e-2953-45f2-b692-64234b9ca8e7"},"_deposit":{"created_by":1,"id":"71632","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71632"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071632","sets":["10:28"]},"author_link":["704788","704778","704784","704779","704791","704777","704786","704782","704775","704789","704793","704783","704776","704781","704785","704787","704774","704780","704790","704792"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-12-01","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】我々はPET用タウイメージング剤である[11C]PBB3を開発した。[11C]PBB3 PETにて進行性核上性麻痺(PSP)および大脳基底核変性症(CBS)におけるタウ蛋白の脳内蓄積を検出できるかどうかを検討する。【対象および方法】対象はPSP11例(69±8歳)、CBS9例(68±7歳)、健常高齢者21例（67±6歳）である。これらの被験者に研究内容を説明し文書にて同意を得た。[11C]PBB3を約12mCi静脈投与し、Siemens HR+スキャナーにて70分間経時的脳内放射能を測定した。同日に[11C]PIB PETを行った。[11C]PBB3投与30-50分後のPET画像をMRI T1画像を用いて解剖学的標準化し、小脳皮質を参照領域としてSUVR画像を作成した。SPM8で3群間においてANOVA解析した。【結果】PIB陽性の健常者2例、CBS2例をSPM解析の対象から除外した。PSP群では中脳、淡蒼球、視床、視床下部、前頭から頭頂皮質に健常群と比較してPBB3の集積がみられた（p < 0.01(unc), extent thresh hold > 50）。CBS群では健常群と比較して前頭から頭頂皮質に高い集積がみられ、その集積はPSP群よりも高い傾向がみられた。【結論】[11C]PBB3 PETにて非アルツハイマー病タオオパシーのタウ病変を捉えることができる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第33回日本認知症学会学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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真希子"}],"nameIdentifiers":[{"nameIdentifier":"704780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"704781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"704782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"704783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 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