{"_buckets": {"deposit": "ec097b38-10da-41e6-8421-746b55e3a2d1"}, "_deposit": {"created_by": 1, "id": "71616", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "71616"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00071616", "sets": ["28"]}, "author_link": ["704469", "704459", "704461", "704466", "704453", "704462", "704448", "704450", "704449", "704456", "704455", "704472", "704467", "704458", "704447", "704454", "704464", "704474", "704463", "704475", "704465", "704452", "704468", "704457", "704460", "704471", "704473", "704470", "704451"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2013-05-30", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【目的】認知症を伴うレヴィ小体病(LBD)において, 脳内β-アミロイド(Aβ)沈着が\nAlzheimer病(AD)様の脳萎縮と関連するか否かを検討する.\n【方法】全被験者に口頭と書面による説明を行い, 本人ないしは家族から研究に参加する\n旨の同意書を書面で得た. LBD15例(レヴィ小体型認知症8例, 認知症を伴うParkinson病7例)\nおよび晩発性AD13例を対象とした. 健常対照に関しては, 神経疾患の既往が無く, 身体診\n察で明らかな異常を認めない22例を対象とし, そのうち[11C]PIB PETの分布容積比画像を\n用いて視覚的にAβ沈着陽性（Aβ(+)）と判断した5例を除いた17例を対象にして, 以下の\n解析を行った. [11C]PIB PETを用いて脳内Aβ沈着を測定し, Aβ沈着の有無でLBDを二群\nに分けた. PET検査と同日に3D-T1強調MRI画像の撮像も行い, voxel-based morphometryによ\nり灰白質容積の推定を行った. 灰白質容積に関し各群間のボクセル統計解析及び関心領域\n解析を行い, 各群間における脳萎縮を比較した. 脳萎縮の比較には, 総頭蓋内容積と年齢を\n共変量としたANCOVA による統計検定を行った.\n【結果】LBD15例中40％の症例とAD群全例でAβ沈着を認めた. 健常対照と比較し, Aβ沈\n着陰性(Aβ(-))LBD群では有意な脳萎縮を認めず, 一方Aβ(+)LBD群では傍海馬領域, 側頭\n頭頂葉等にAD様の軽度脳萎縮を認め, その分布の95%はAD群の脳萎縮と一致した. 健常対\n照と比較し, 傍海馬領域の灰白質容積は, AD群およびAβ(+)LBD群では26％(p \u003c 0.001, p =\n0.002), Aβ(-)LBD群では10％(p = 1.000)減少していた.\n【結論】LBD患者において, 脳内Aβ沈着は傍海馬領域の萎縮を含むAD様の脳萎縮と関連\nしていた.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "第54回 日本神経学会学術大会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "島田, 斉"}], "nameIdentifiers": [{"nameIdentifier": "704447", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平野, 成樹"}], "nameIdentifiers": [{"nameIdentifier": "704448", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠, 仁"}], "nameIdentifiers": [{"nameIdentifier": "704449", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古川, 彰吾"}], "nameIdentifiers": [{"nameIdentifier": "704450", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "江口, 洋子"}], "nameIdentifiers": [{"nameIdentifier": "704451", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畑, 圭輔"}], "nameIdentifiers": [{"nameIdentifier": "704452", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小高, 文聰"}], "nameIdentifiers": [{"nameIdentifier": "704453", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原, 広臨"}], "nameIdentifiers": [{"nameIdentifier": "704454", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村, 泰之"}], "nameIdentifiers": [{"nameIdentifier": "704455", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 真希子"}], "nameIdentifiers": [{"nameIdentifier": "704456", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高野, 晴成"}], "nameIdentifiers": [{"nameIdentifier": "704457", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤, 浩"}], "nameIdentifiers": [{"nameIdentifier": "704458", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口, 真人"}], "nameIdentifiers": [{"nameIdentifier": "704459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原, 哲也"}], "nameIdentifiers": [{"nameIdentifier": "704460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "704461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田 斉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704462", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平野 成樹", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠 仁", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704464", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古川 彰吾", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704465", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "江口 洋子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704466", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畑 圭輔", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704467", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小高 文聰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704468", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原 広臨", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704469", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村 泰之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704470", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田 真希子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704471", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高野 晴成", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤 浩", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口 真人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704474", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 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