{"created":"2023-05-15T14:52:27.208833+00:00","id":71616,"links":{},"metadata":{"_buckets":{"deposit":"ec097b38-10da-41e6-8421-746b55e3a2d1"},"_deposit":{"created_by":1,"id":"71616","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71616"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071616","sets":["10:28"]},"author_link":["704469","704459","704461","704466","704453","704462","704448","704450","704449","704456","704455","704472","704467","704458","704447","704454","704464","704474","704463","704475","704465","704452","704468","704457","704460","704471","704473","704470","704451"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】認知症を伴うレヴィ小体病(LBD)において, 脳内β-アミロイド(Aβ)沈着が\nAlzheimer病(AD)様の脳萎縮と関連するか否かを検討する.\n【方法】全被験者に口頭と書面による説明を行い, 本人ないしは家族から研究に参加する\n旨の同意書を書面で得た. LBD15例(レヴィ小体型認知症8例, 認知症を伴うParkinson病7例)\nおよび晩発性AD13例を対象とした. 健常対照に関しては, 神経疾患の既往が無く, 身体診\n察で明らかな異常を認めない22例を対象とし, そのうち[11C]PIB PETの分布容積比画像を\n用いて視覚的にAβ沈着陽性（Aβ(+)）と判断した5例を除いた17例を対象にして, 以下の\n解析を行った. [11C]PIB PETを用いて脳内Aβ沈着を測定し, Aβ沈着の有無でLBDを二群\nに分けた. PET検査と同日に3D-T1強調MRI画像の撮像も行い, voxel-based morphometryによ\nり灰白質容積の推定を行った. 灰白質容積に関し各群間のボクセル統計解析及び関心領域\n解析を行い, 各群間における脳萎縮を比較した. 脳萎縮の比較には, 総頭蓋内容積と年齢を\n共変量としたANCOVA による統計検定を行った.\n【結果】LBD15例中40％の症例とAD群全例でAβ沈着を認めた. 健常対照と比較し, Aβ沈\n着陰性(Aβ(-))LBD群では有意な脳萎縮を認めず, 一方Aβ(+)LBD群では傍海馬領域, 側頭\n頭頂葉等にAD様の軽度脳萎縮を認め, その分布の95%はAD群の脳萎縮と一致した. 健常対\n照と比較し, 傍海馬領域の灰白質容積は, AD群およびAβ(+)LBD群では26％(p < 0.001, p =\n0.002), Aβ(-)LBD群では10％(p = 1.000)減少していた.\n【結論】LBD患者において, 脳内Aβ沈着は傍海馬領域の萎縮を含むAD様の脳萎縮と関連\nしていた.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第54回 日本神経学会学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"704447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"704448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"704449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 彰吾"}],"nameIdentifiers":[{"nameIdentifier":"704450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"704451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑, 圭輔"}],"nameIdentifiers":[{"nameIdentifier":"704452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高, 文聰"}],"nameIdentifiers":[{"nameIdentifier":"704453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 広臨"}],"nameIdentifiers":[{"nameIdentifier":"704454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"704455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 真希子"}],"nameIdentifiers":[{"nameIdentifier":"704456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"704457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"704458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"704459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"704460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"704461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 彰吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 広臨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704475","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"レヴィ小体病におけるアミロイド沈着はアルツハイマー病様脳萎縮と関連する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レヴィ小体病におけるアミロイド沈着はアルツハイマー病様脳萎縮と関連する"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-20"},"publish_date":"2015-04-20","publish_status":"0","recid":"71616","relation_version_is_last":true,"title":["レヴィ小体病におけるアミロイド沈着はアルツハイマー病様脳萎縮と関連する"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:49:15.001247+00:00"}