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Progesterone generates breast cancer stem cells through PR-independent mechanisms in irradiated human mammary cell lines
https://repo.qst.go.jp/records/71529
https://repo.qst.go.jp/records/71529301d1b93-373b-4cd8-9ffd-1059aec3a35f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-21 | |||||
| タイトル | ||||||
| タイトル | Progesterone generates breast cancer stem cells through PR-independent mechanisms in irradiated human mammary cell lines | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ｇｕｉｌｌａｕｍｅ
× Ｇｕｉｌｌａｕｍｅ× 崔, 星× 王, 冰× 中島, 徹夫× 根井, 充× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 崔 星× 王 冰× 中島 徹夫× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chest radiation exposure was shown to increase breast cancer risk. Steroid hormones are known to influence radiosensitivity and breast cancer risk. Tumors may be initiated by a small subpopulation of cancer stem cells (CSCs). In order to evaluate whether the modulation of radiation-induced breast cancer risk by steroid hormones could involve CSCs, we measured the proportion of ALDH+ and CD44+/CD24- CSCs in irradiated breast cancer cell lines after steroid hormone treatment. Progesterone stimulated the expansion of the CSC compartment both in PR+ breast cancer cells and in PR- normal cells. In MCF10A normal epithelial PR- cells, progesterone treatment and irradiation triggered cancer and stemness-associated microRNA regulations (such as the down-regulation of miR-22 and miR-29c expression), which resulted in increased proportions of radiation-resistant CSCs. Thus progesterone might influence radiation-induced breast cancer risk by generating tumor-initiating breast CSCs through nuclear PR-independent mechanisms, such as membrane progesterone receptors. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第73回日本癌学会学術総会に参加し、発表する。 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-09-25 | |||||
| 日付タイプ | Issued | |||||
