{"created":"2023-05-15T14:52:23.374358+00:00","id":71529,"links":{},"metadata":{"_buckets":{"deposit":"1ab6afdf-bf06-40a1-9d62-73e55531e082"},"_deposit":{"created_by":1,"id":"71529","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71529"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071529","sets":["10:28"]},"author_link":["703367","703370","703368","703373","703369","703375","703366","703372","703371","703374"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-09-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chest radiation exposure was shown to increase breast cancer risk. Steroid hormones are known to influence radiosensitivity and breast cancer risk. Tumors may be initiated by a small subpopulation of cancer stem cells (CSCs). In order to evaluate whether the modulation of radiation-induced breast cancer risk by steroid hormones could involve CSCs, we measured the proportion of ALDH+ and CD44+/CD24- CSCs in irradiated breast cancer cell lines after steroid hormone treatment. Progesterone stimulated the expansion of the CSC compartment both in PR+ breast cancer cells and in PR- normal cells. In MCF10A normal epithelial PR- cells, progesterone treatment and irradiation triggered cancer and stemness-associated microRNA regulations (such as the down-regulation of miR-22 and miR-29c expression), which resulted in increased proportions of radiation-resistant CSCs. Thus progesterone might influence radiation-induced breast cancer risk by generating tumor-initiating breast CSCs through nuclear PR-independent mechanisms, such as membrane progesterone receptors.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第73回日本癌学会学術総会に参加し、発表する。","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ"}],"nameIdentifiers":[{"nameIdentifier":"703366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔, 星"}],"nameIdentifiers":[{"nameIdentifier":"703367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"703368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"703369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井, 充"}],"nameIdentifiers":[{"nameIdentifier":"703370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"703375","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Progesterone generates breast cancer stem cells through PR-independent mechanisms in irradiated human mammary cell lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Progesterone generates breast cancer stem cells through PR-independent mechanisms in irradiated human mammary cell lines"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-21"},"publish_date":"2014-10-21","publish_status":"0","recid":"71529","relation_version_is_last":true,"title":["Progesterone generates breast cancer stem cells through PR-independent mechanisms in irradiated human mammary cell lines"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:50:11.289747+00:00"}