@misc{oai:repo.qst.go.jp:00071529,
 author = {Ｇｕｉｌｌａｕｍｅ and 崔, 星 and 王, 冰 and 中島, 徹夫 and 根井, 充 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 崔 星 and 王 冰 and 中島 徹夫 and 根井 充},
 month = {Sep},
 note = {Chest radiation exposure was shown to increase breast cancer risk. Steroid hormones are known to influence radiosensitivity and breast cancer risk. Tumors may be initiated by a small subpopulation of cancer stem cells (CSCs). In order to evaluate whether the modulation of radiation-induced breast cancer risk by steroid hormones could involve CSCs, we measured the proportion of ALDH+ and CD44+/CD24- CSCs in irradiated breast cancer cell lines after steroid hormone treatment. Progesterone stimulated the expansion of the CSC compartment both in PR+ breast cancer cells and in PR- normal cells. In MCF10A normal epithelial PR- cells, progesterone treatment and irradiation triggered cancer and stemness-associated microRNA regulations (such as the down-regulation of miR-22 and miR-29c expression), which resulted in increased proportions of radiation-resistant CSCs. Thus progesterone might influence radiation-induced breast cancer risk by generating tumor-initiating breast CSCs through nuclear PR-independent mechanisms, such as membrane progesterone receptors., 第73回日本癌学会学術総会に参加し、発表する。},
 title = {Progesterone generates breast cancer stem cells through PR-independent mechanisms in irradiated human mammary cell lines},
 year = {2014}
}