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Irradiation on CD180-negative B Cells
https://repo.qst.go.jp/records/71397
https://repo.qst.go.jp/records/713979f690587-aa26-4e7d-8454-b283d4506995
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-24 | |||||
| タイトル | ||||||
| タイトル | Irradiation on CD180-negative B Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
藤田, 和子
× 藤田, 和子× 桑原, 卓× 王, 冰× 田中, 薫× Yoshikiyo, AKASAKA× Tetuo, MIKAMI× 藤田 和子× 桑原 卓× 王 冰× 田中 薫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CD180, a homologue of TLR-4, is a key regulator of cell proliferation and death, showing a protective effect against radiation-induced apoptosis. SLE patients exhibit the increased number of CD180-negative B cells in blood, which appears to be associated with the activity of SLE. The production of autoantibodies was found on CD180-negative cells from SLE patients. In SLE-model NZBWF1 mouse, we previously reported the increased number of CD180-negative B cells with development of SLE morbidity and the production of autoantibodies by CD180-negative cells. We also showed CD180-negative cells were more radiosensitive than CD180-positive cells. These suggest that radiation may lead to selective elimination of CD180- negative cells, resulting in a decrease in the production of autoantibodies in SLE. We therefore attempted to examine the effects of X-ray irradiation on CD180-negative cells in NZBWF1 female mice. After the onset of symptoms, mice were paired according to their severity. In each pair, one mouse was irradiated by 4 Gy sealing her head, and the other was shamirradiated. Compared to the sham-irradiated mice, the mean number of CD180-negative cells in spleen from irradiated mice was significantly decreased, and the mean life span was markedly extended. The latency to the development of grade three-proteinuria in irradiated mice is also remarkably greater than that in sham-irradiated mice. Within each pair, the life span of the irradiated mice was significantly longer than that of the paired sham-irradiated mice. These suggest that radiation could effectively elim inate CD180-negative B cells, leading to reduction of autoantibody production, and consequently relieve the SLE symptoms in mouse. These also suggest a possibility that the radiotherapy into autoimmune diseases associated with the expression of CD180-negative cells might be a novel practical application |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annual meeting of The Japanese Society for Immunology（2013第42回日本免疫学会学術集会）. | |||||
| 発表年月日 | ||||||
| 日付 | 2013-12-11 | |||||
| 日付タイプ | Issued | |||||
