@misc{oai:repo.qst.go.jp:00071397,
 author = {藤田, 和子 and 桑原, 卓 and 王, 冰 and 田中, 薫 and Yoshikiyo, AKASAKA and Tetuo, MIKAMI and 藤田 和子 and 桑原 卓 and 王 冰 and 田中 薫},
 month = {Dec},
 note = {CD180, a homologue of TLR-4, is a key regulator of cell proliferation and
death, showing a protective effect against radiation-induced apoptosis. SLE
patients exhibit the increased number of CD180-negative B cells in blood,
which appears to be associated with the activity of SLE. The production of
autoantibodies was found on CD180-negative cells from SLE patients. In
SLE-model NZBWF1 mouse, we previously reported the increased number
of CD180-negative B cells with development of SLE morbidity and the
production of autoantibodies by CD180-negative cells. We also showed
CD180-negative cells were more radiosensitive than CD180-positive cells.
These suggest that radiation may lead to selective elimination of CD180-
negative cells, resulting in a decrease in the production of autoantibodies
in SLE. We therefore attempted to examine the effects of X-ray irradiation
on CD180-negative cells in NZBWF1 female mice. After the onset of
symptoms, mice were paired according to their severity. In each pair, one　
mouse was irradiated by 4 Gy sealing her head, and the other was shamirradiated.
Compared to the sham-irradiated mice, the mean number of
CD180-negative cells in spleen from irradiated mice was significantly
decreased, and the mean life span was markedly extended. The latency to
the development of grade three-proteinuria in irradiated mice is also
remarkably greater than that in sham-irradiated mice. Within each pair,
the life span of the irradiated mice was significantly longer than that of the
paired sham-irradiated mice. These suggest that radiation could effectively
elim inate CD180-negative B cells, leading to reduction of autoantibody
production, and consequently relieve the SLE symptoms in mouse. These
also suggest a possibility that the radiotherapy into autoimmune diseases
associated with the expression of CD180-negative cells might be a novel
practical application, Annual meeting of The Japanese Society for Immunology（2013第42回日本免疫学会学術集会）.},
 title = {Irradiation on CD180-negative B Cells},
 year = {2013}
}