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Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation
https://repo.qst.go.jp/records/70731
https://repo.qst.go.jp/records/7073105d28da4-a441-4fc9-ab1b-3b18037e2335
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-04-25 | |||||
| タイトル | ||||||
| タイトル | Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hong, Zhang
× Hong, Zhang× Wang, Yanling× Bing, Wang× Tanaka, Kaoru× Ninomiya, Yasuharu× Li, Ning× Zhou, Xin× Wang, Zhenhua× Xie, Yi× Ｈｏｎｇ Ｚｈａｎｇ× Ｗａｎｇ Ｙａｎｌｉｎｇ× 王 冰× 田中 薫× 二宮 康晴× Ｚｈｏｕ Ｘｉｎ× Ｗａｎｇ Ｚｈｅｎｈｕａ× Ｘｉｅ Ｙｉ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Our previous works provided evidence that carbon-ion irradiation could repress telomerase activity via BRCA1 regulation in MCF-7 cells. It was proposed that telomerase inhibition could result in telomere shortening, followed by proliferation arrest and cell death. However, telomere shortening was not observed after X-ray or heavy-ion irradiation in our current study. To further understand the regulatory pathway between BRCA1 and telomere, DNA-PKcs, as a downstream effector of BRCA1, was investigated. Inhibition of DNA-PKcs led to significant loss of cell viability via apoptosis and senescence. It was reported that the human telomerase RNA component, hTR, stimulated the kinase activity of DNA-PKcs. These data suggested that the telomerase regulation was mediated by BRCA1 and DNA-PKcs, in-depth investigation about the effect of telomerase activity on radiosensitivity should be carried out. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成23年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-04-24 | |||||
| 日付タイプ | Issued | |||||
