{"created":"2023-05-15T14:51:44.532837+00:00","id":70731,"links":{},"metadata":{"_buckets":{"deposit":"dade5d7f-b5a8-4455-8fb3-f930097fe19f"},"_deposit":{"created_by":1,"id":"70731","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70731"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070731","sets":["10:28"]},"author_link":["694799","694793","694800","694791","694798","694803","694796","694802","694807","694795","694806","694801","694797","694804","694805","694792","694794"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-04-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Our previous works provided evidence that carbon-ion irradiation could repress telomerase activity via BRCA1 regulation in MCF-7 cells. It was proposed that telomerase inhibition could result in telomere shortening, followed by proliferation arrest and cell death. However, telomere shortening was not observed after X-ray or heavy-ion irradiation in our current study. To further understand the regulatory pathway between BRCA1 and telomere, DNA-PKcs, as a downstream effector of BRCA1, was investigated. Inhibition of DNA-PKcs led to significant loss of cell viability via apoptosis and senescence. It was reported that the human telomerase RNA component, hTR, stimulated the kinase activity of DNA-PKcs. These data suggested that the telomerase regulation was mediated by BRCA1 and DNA-PKcs, in-depth investigation about the effect of telomerase activity on radiosensitivity should be carried out.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成23年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"694791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Yanling"}],"nameIdentifiers":[{"nameIdentifier":"694792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"694793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"694794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"694795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Ning"}],"nameIdentifiers":[{"nameIdentifier":"694796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhou, Xin"}],"nameIdentifiers":[{"nameIdentifier":"694797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Zhenhua"}],"nameIdentifiers":[{"nameIdentifier":"694798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Yi"}],"nameIdentifiers":[{"nameIdentifier":"694799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｈｏｎｇ Ｚｈａｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｗａｎｇ Ｙａｎｌｉｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｚｈｏｕ Ｘｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｗａｎｇ Ｚｈｅｎｈｕａ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｘｉｅ Ｙｉ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694807","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-04-25"},"publish_date":"2012-04-25","publish_status":"0","recid":"70731","relation_version_is_last":true,"title":["Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:31.099101+00:00"}