@misc{oai:repo.qst.go.jp:00070731,
 author = {Hong, Zhang and Wang, Yanling and Bing, Wang and Tanaka, Kaoru and Ninomiya, Yasuharu and Li, Ning and Zhou, Xin and Wang, Zhenhua and Xie, Yi and Ｈｏｎｇ Ｚｈａｎｇ and Ｗａｎｇ Ｙａｎｌｉｎｇ and 王 冰 and 田中 薫 and 二宮 康晴 and Ｚｈｏｕ Ｘｉｎ and Ｗａｎｇ Ｚｈｅｎｈｕａ and Ｘｉｅ Ｙｉ},
 month = {Apr},
 note = {Our previous works provided evidence that carbon-ion irradiation could repress telomerase activity via BRCA1 regulation in MCF-7 cells. It was proposed that telomerase inhibition could result in telomere shortening, followed by proliferation arrest and cell death. However, telomere shortening was not observed after X-ray or heavy-ion irradiation in our current study. To further understand the regulatory pathway between BRCA1 and telomere, DNA-PKcs, as a downstream effector of BRCA1, was investigated. Inhibition of DNA-PKcs led to significant loss of cell viability via apoptosis and senescence. It was reported that the human telomerase RNA component, hTR, stimulated the kinase activity of DNA-PKcs. These data suggested that the telomerase regulation was mediated by BRCA1 and DNA-PKcs, in-depth investigation about the effect of telomerase activity on radiosensitivity should be carried out., 平成23年度HIMAC共同利用研究成果発表会},
 title = {Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation},
 year = {2012}
}