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Radical-Scavenging Activity of 6-Chromanol Derivatives with Various Substituents
https://repo.qst.go.jp/records/70639
https://repo.qst.go.jp/records/706394a6085b9-d105-42fe-b08c-e685fa15d1ce
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-11-24 | |||||
| タイトル | ||||||
| タイトル | Radical-Scavenging Activity of 6-Chromanol Derivatives with Various Substituents | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Inami, Keiko× Ohkubo, Kei× Kawashima, Tomonori× Fukuhara, Kiyoshi× Fukuzumi, Shunichi× Anzai, Kazunori× Ozawa, Toshihiko× Mochizuki, Masataka× Matsumoto, Kenichiro× 中西 郁夫× 川島 知憲× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The radical-scavenging rates of alpha-tocopherol and 6-chromanol derivatives with various substituents were examined in order to develop effective radioprotectors. alpha-Tocopherol efficiently scavenged galvinoxyl radical (GO) with the second-order rate constant (k) of 3.3 x 10(3) M(-1) s(-1) in deaerated acetonitrile at 25 degrees C. When the phytyl group at the C2 position in alpha-tocopherol was replaced by methyl group, no significant change was observed [k = 3.2 x 10(3) M(-1) s(-1)]. On the other hand, a carboxyl group at the C2 position significantly retarded the GO-scavenging rate [k = 4.9 x 10(2) M(-1) s(-1)]. Among the 6-chromanol derivatives, 8-amino-2,2-dimethylchroman-6-ol showed the highest GO-scavenging activity [k = 1.4 x 10(4) M(-1) s(-1)]. The smaller the calculated ionization potential by the density functional theory is, the stronger the GO-scavenging activity becomes. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) | |||||
| 発表年月日 | ||||||
| 日付 | 2011-11-20 | |||||
| 日付タイプ | Issued | |||||
