@misc{oai:repo.qst.go.jp:00070639,
 author = {Nakanishi, Ikuo and Inami, Keiko and Ohkubo, Kei and Kawashima, Tomonori and Fukuhara, Kiyoshi and Fukuzumi, Shunichi and Anzai, Kazunori and Ozawa, Toshihiko and Mochizuki, Masataka and Matsumoto, Kenichiro and 中西 郁夫 and 川島 知憲 and 松本 謙一郎},
 month = {Nov},
 note = {The radical-scavenging rates of alpha-tocopherol and 6-chromanol derivatives with various substituents were examined in order to develop effective radioprotectors.  alpha-Tocopherol efficiently scavenged galvinoxyl radical (GO) with the second-order rate constant (k) of 3.3 x 10(3) M(-1) s(-1) in deaerated acetonitrile at 25 degrees C.  When the phytyl group at the C2 position in alpha-tocopherol was replaced by methyl group, no significant change was observed [k = 3.2 x 10(3) M(-1) s(-1)].  On the other hand, a carboxyl group at the C2 position significantly retarded the GO-scavenging rate [k = 4.9 x 10(2) M(-1) s(-1)].  Among the 6-chromanol derivatives, 8-amino-2,2-dimethylchroman-6-ol showed the highest GO-scavenging activity [k = 1.4 x 10(4) M(-1) s(-1)].  The smaller the calculated ionization potential by the density functional theory is, the stronger the GO-scavenging activity becomes., 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011)},
 title = {Radical-Scavenging Activity of 6-Chromanol Derivatives with Various Substituents},
 year = {2011}
}