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Anti-metastatic effects of carbon-ion beams for malignant tumors
https://repo.qst.go.jp/records/70576
https://repo.qst.go.jp/records/7057631551683-b9fa-4ad0-84ed-42d9ce36e32b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-16 | |||||
| タイトル | ||||||
| タイトル | Anti-metastatic effects of carbon-ion beams for malignant tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Uzawa, Akiko× Hirayama, Ryoichi× Koike, Sachiko× Tsuruoka, Chizuru× Wada, Mami× Okayasu, Ryuichi× Ando, Koichi× Furusawa, Yoshiya× et.al× 松本 孔貴× 鵜澤 玲子× 平山 亮一× 小池 幸子× 鶴岡 千鶴× 和田 麻美× 岡安 隆一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Up to 2011, over 5500 patients have been treated in HIMAC. Malignant melanoma showed high local control about 75%, whereas the overall survival was about 36% at 5-years. It is an important subject to control tumor distant metastasis for heavy-ion radiotherapy. The aim of this study is to clarify the effect of carbon ion beams (C-ions) on metastatic potential of melanoma in vitro and in vivo. Materials and Methods: A highly metastatic mouse malignant melanoma cell line, B16/BL6 was maintained in RPMI-1640 medium supplemented with 10% FBS and antibiotics. [in vitro] Samples were prepared 1.5 days before and then irradiated with C-ions at different LETs or X-rays. Surviving fractions (SF) and metastatic potentials (migration, invasion and adhesion activity) of the cells were examined. [in vivo] Local tumors implanted into right leg of mice were also irradiated with C-ions at different LETs, or gamma-rays. The metastatic effects were analyzed with the spontaneous lung metastasis model. Radiosensitivity for individual cell in a tumor was obtained by an in vivo-in vitro assay. Results: [in vitro] C-ions showed higher cytotoxic and anti-metastatic effects compared with X-rays, and the effects were significant depend on dose and LET values. The enhancement ratios obtained from metastatic potential were higher than that from cell killing. [in vivo] After irradiation for local tumors, the numbers of lung metastatic nodules decreased with the dose and LET values. C-ions were more effective compared with gamma-rays. The number of lung metastasis was analyzed with equivalent survival dose at D10 calculated form the survival curves of individual cell in a tumor. In this case, C-ions also showed smaller number of metastasis than gamma-rays. Conclusion: It might suggest that C-ions inhibit metastasis at radiotherapy compared with photons. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14th International Congress of Radiation Research (ICRR2011) | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-01 | |||||
| 日付タイプ | Issued | |||||
