WEKO3
-
RootNode
アイテム
Anti-metastatic effects of carbon-ion beams for malignant tumors
https://repo.qst.go.jp/records/70576
https://repo.qst.go.jp/records/7057631551683-b9fa-4ad0-84ed-42d9ce36e32b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-16 | |||||
| タイトル | ||||||
| タイトル | Anti-metastatic effects of carbon-ion beams for malignant tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Uzawa, Akiko× Hirayama, Ryoichi× Koike, Sachiko× Tsuruoka, Chizuru× Wada, Mami× Okayasu, Ryuichi× Ando, Koichi× Furusawa, Yoshiya× et.al× 松本 孔貴× 鵜澤 玲子× 平山 亮一× 小池 幸子× 鶴岡 千鶴× 和田 麻美× 岡安 隆一× 古澤 佳也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Up to 2011, over 5500 patients have been treated in HIMAC. Malignant melanoma showed high local control about 75%, whereas the overall survival was about 36% at 5-years. It is an important subject to control tumor distant metastasis for heavy-ion radiotherapy. The aim of this study is to clarify the effect of carbon ion beams (C-ions) on metastatic potential of melanoma in vitro and in vivo. Materials and Methods: A highly metastatic mouse malignant melanoma cell line, B16/BL6 was maintained in RPMI-1640 medium supplemented with 10% FBS and antibiotics. [in vitro] Samples were prepared 1.5 days before and then irradiated with C-ions at different LETs or X-rays. Surviving fractions (SF) and metastatic potentials (migration, invasion and adhesion activity) of the cells were examined. [in vivo] Local tumors implanted into right leg of mice were also irradiated with C-ions at different LETs, or gamma-rays. The metastatic effects were analyzed with the spontaneous lung metastasis model. Radiosensitivity for individual cell in a tumor was obtained by an in vivo-in vitro assay. Results: [in vitro] C-ions showed higher cytotoxic and anti-metastatic effects compared with X-rays, and the effects were significant depend on dose and LET values. The enhancement ratios obtained from metastatic potential were higher than that from cell killing. [in vivo] After irradiation for local tumors, the numbers of lung metastatic nodules decreased with the dose and LET values. C-ions were more effective compared with gamma-rays. The number of lung metastasis was analyzed with equivalent survival dose at D10 calculated form the survival curves of individual cell in a tumor. In this case, C-ions also showed smaller number of metastasis than gamma-rays. Conclusion: It might suggest that C-ions inhibit metastasis at radiotherapy compared with photons. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14th International Congress of Radiation Research (ICRR2011) | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-01 | |||||
| 日付タイプ | Issued | |||||
Share
Cite as
Matsumoto, Yoshitaka, Uzawa, Akiko, Hirayama, Ryoichi, Koike, Sachiko, Tsuruoka, Chizuru, Wada, Mami, Okayasu, Ryuichi, Ando, Koichi, Furusawa, Yoshiya, et.al, 松本 孔貴, 鵜澤 玲子, 平山 亮一, 小池 幸子, 鶴岡 千鶴, 和田 麻美, 岡安 隆一, 古澤 佳也, 2011, Anti-metastatic effects of carbon-ion beams for malignant tumors.
Loading...
