{"created":"2023-05-15T14:51:37.749803+00:00","id":70576,"links":{},"metadata":{"_buckets":{"deposit":"c5b90d6e-ff54-4e7e-8905-e061289018e7"},"_deposit":{"created_by":1,"id":"70576","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70576"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070576","sets":["10:28"]},"author_link":["693133","693146","693145","693140","693134","693136","693132","693143","693137","693144","693135","693147","693139","693149","693148","693141","693142","693138"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-09-01","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Up to 2011, over 5500 patients have been treated in HIMAC. Malignant melanoma showed high local control about 75%, whereas the overall survival was about 36% at 5-years. It is an important subject to control tumor distant metastasis for heavy-ion radiotherapy. The aim of this study is to clarify the effect of carbon ion beams (C-ions) on metastatic potential of melanoma in vitro and in vivo.  Materials and Methods: A highly metastatic mouse malignant melanoma cell line, B16/BL6 was maintained in RPMI-1640 medium supplemented with 10% FBS and antibiotics. [in vitro] Samples were prepared 1.5 days before and then irradiated with C-ions at different LETs or X-rays. Surviving fractions (SF) and metastatic potentials (migration, invasion and adhesion activity) of the cells were examined. [in vivo] Local tumors implanted into right leg of mice were also irradiated with C-ions at different LETs, or gamma-rays. The metastatic effects were analyzed with the spontaneous lung metastasis model. Radiosensitivity for individual cell in a tumor was obtained by an in vivo-in vitro assay.  Results: [in vitro] C-ions showed higher cytotoxic and anti-metastatic effects compared with X-rays, and the effects were significant depend on dose and LET values. The enhancement ratios obtained from metastatic potential were higher than that from cell killing. [in vivo] After irradiation for local tumors, the numbers of lung metastatic nodules decreased with the dose and LET values. C-ions were more effective compared with gamma-rays. The number of lung metastasis was analyzed with equivalent survival dose at D10 calculated form the survival curves of individual cell in a tumor. In this case, C-ions also showed smaller number of metastasis than gamma-rays.  Conclusion: It might suggest that C-ions inhibit metastasis at radiotherapy compared with photons.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"14th International Congress of Radiation Research (ICRR2011)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"693132","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uzawa, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"693133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"693134","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"693135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuruoka, Chizuru"}],"nameIdentifiers":[{"nameIdentifier":"693136","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wada, Mami"}],"nameIdentifiers":[{"nameIdentifier":"693137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"693138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"693139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"693140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"693141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田 麻美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693149","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Anti-metastatic effects of carbon-ion beams for malignant tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-metastatic effects of carbon-ion beams for malignant tumors"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-16"},"publish_date":"2011-10-16","publish_status":"0","recid":"70576","relation_version_is_last":true,"title":["Anti-metastatic effects of carbon-ion beams for malignant tumors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:01:19.466032+00:00"}