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Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation
https://repo.qst.go.jp/records/70529
https://repo.qst.go.jp/records/70529e6d5adca-a72e-4f3c-ad0a-9310cf4edf3c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-09-14 | |||||
| タイトル | ||||||
| タイトル | Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshii, Yukie
× Yoshii, Yukie× Yoneda, Makoto× Ikawa, Masamichi× Furukawa, Takako× Kiyono, Yashushi× Mori, Hiroshi× Yoshii, Hiroshi× Oyama, Nobuyuki× Okazawa, Hidehiko× Saga, Tsuneo× Fujibayashi, Yasuhisa× 吉井 幸恵× 古川 高子× 森 啓× 吉井 裕× 佐賀 恒夫× 藤林 康久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Radiolabeled Cu-diacetyl-bis (N4-methylthiosemicarbazone) (*Cu-ATSM), including 60/62/64Cu-ATSM, is a potential imaging agent of hypoxic tumors for use with PET. We have reported that *Cu-ATSM is trapped in tumor cells under over-reduced states, such as hypoxia. In this study, to evaluate *Cu-ATSM as an indicator of intracellular over-reduced states in disorders with mitochondrial dysfunction, we examined correlation between *Cu-ATSM uptake and levels of biological reductant NADH and NADPH with mtDNA (mitochondria DNA)-less 0 cells and the parental 143B human osteosarcoma cells and with 0-cybrids carrying mutated mitochondria from a patient of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) (2SD cells) and that carrying wild-type one (2SA cells). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2011 World Molecular Imaging Congress (Wmic) | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-10 | |||||
| 日付タイプ | Issued | |||||
