@misc{oai:repo.qst.go.jp:00070529,
 author = {Yoshii, Yukie and Yoneda, Makoto and Ikawa, Masamichi and Furukawa, Takako and Kiyono, Yashushi and Mori, Hiroshi and Yoshii, Hiroshi and Oyama, Nobuyuki and Okazawa, Hidehiko and Saga, Tsuneo and Fujibayashi, Yasuhisa and 吉井 幸恵 and 古川 高子 and 森 啓 and 吉井 裕 and 佐賀 恒夫 and 藤林 康久},
 month = {Sep},
 note = {Introduction: Radiolabeled Cu-diacetyl-bis (N4-methylthiosemicarbazone) (*Cu-ATSM), including 60/62/64Cu-ATSM, is a potential imaging agent of hypoxic tumors for use with PET. We have reported that *Cu-ATSM is trapped in tumor cells under over-reduced states, such as hypoxia. In this study, to evaluate *Cu-ATSM as an indicator of intracellular over-reduced states in disorders with mitochondrial dysfunction, we examined correlation between *Cu-ATSM uptake and levels of biological reductant NADH and NADPH with mtDNA (mitochondria DNA)-less 0 cells and the parental 143B human osteosarcoma cells and with 0-cybrids carrying mutated mitochondria from a patient of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) (2SD cells) and that carrying wild-type one (2SA cells)., 2011 World Molecular Imaging Congress (Wmic)},
 title = {Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation},
 year = {2011}
}