{"created":"2023-05-15T14:51:35.706467+00:00","id":70529,"links":{},"metadata":{"_buckets":{"deposit":"a3e497dc-d3a4-4935-a24f-22845ab1ae81"},"_deposit":{"created_by":1,"id":"70529","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70529"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070529","sets":["10:28"]},"author_link":["692682","692667","692672","692673","692671","692674","692676","692677","692683","692678","692668","692670","692675","692679","692680","692669","692681"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-09-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Radiolabeled Cu-diacetyl-bis (N4-methylthiosemicarbazone) (*Cu-ATSM), including 60/62/64Cu-ATSM, is a potential imaging agent of hypoxic tumors for use with PET. We have reported that *Cu-ATSM is trapped in tumor cells under over-reduced states, such as hypoxia. In this study, to evaluate *Cu-ATSM as an indicator of intracellular over-reduced states in disorders with mitochondrial dysfunction, we examined correlation between *Cu-ATSM uptake and levels of biological reductant NADH and NADPH with mtDNA (mitochondria DNA)-less 0 cells and the parental 143B human osteosarcoma cells and with 0-cybrids carrying mutated mitochondria from a patient of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) (2SD cells) and that carrying wild-type one (2SA cells).","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"2011 World Molecular Imaging Congress (Wmic)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshii, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"692667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneda, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"692668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikawa, Masamichi"}],"nameIdentifiers":[{"nameIdentifier":"692669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"692670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyono, Yashushi"}],"nameIdentifiers":[{"nameIdentifier":"692671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"692672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshii, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"692673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oyama, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"692674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazawa, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"692675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"692676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujibayashi, Yasuhisa"}],"nameIdentifiers":[{"nameIdentifier":"692677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 啓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林 康久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692683","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-09-14"},"publish_date":"2011-09-14","publish_status":"0","recid":"70529","relation_version_is_last":true,"title":["Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:01:51.658498+00:00"}