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Manganese-enhanced MRI as a molecular imaging of mesothelioma
https://repo.qst.go.jp/records/70240
https://repo.qst.go.jp/records/70240e865f446-7a51-4011-8925-887faca2a6ae
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-14 | |||||
| タイトル | ||||||
| タイトル | Manganese-enhanced MRI as a molecular imaging of mesothelioma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasegawa, Sumitaka
× Hasegawa, Sumitaka× Saito, Shigeyoshi× Morokoshi, Yukie× Furukawa, Takako× Aoki, Ichio× Saga, Tsuneo× 長谷川 純崇× 齋藤 茂芳× 諸越 幸恵× 古川 高子× 青木 伊知男× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To develop a selective diagnostic imaging of mesothelioma by targeting disease-specific biomarkers. Materials and Methods: All experiments were approved by the Institutional Animal Care and Use Committee. Manganese-superoxide dismutase (Mn-SOD) expression was evaluated in one human mesothelial cells and five human malignant mesothelioma (MM) cells. Mn accumulation in NCI-H226 and MSTO-211H MM cells was examined when loaded with Mn. Mn-enhanced magnetic resonance imaging (MEMRI) of those cell pellets and subcutaneous tumors were conducted using 7 Tesla-MRI. Signal enhancement of H226 xenografted pleural tumors was determined by MEMRI with manganese dipyridoxyl diphosphate (MnDPDP) as well as manganese chloride (MnCl2). Results: We found that 4 of 5 human MM cells over-expressed Mn-SOD protein compared to mesothelial cells, and that H226 MM cells highly expressed Mn-SOD and augmented Mn accumulation when loaded with MnCl2. The cells showed marked T1-signal enhancement on in vitro MRI after incubation with MnCl2. H226 subcutaneous tumors were preferentially enhanced compared to MSTO-211H tumors, which had less Mn-SOD expression, in MnCl2-enhanced T1-weighted MR image (T1WI). H226 pleural tumors were markedly enhanced and readily detected by MEMRI using MnDPDP as well as MnCl2. Conclusion: We propose that MEMRI can be a potentially powerful method for non-invasive detection of MM with high spatial resolution and marked signal enhancement by targeting Mn-SOD. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | World Molecular Imaging Congress 2010 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-11 | |||||
| 日付タイプ | Issued | |||||
