{"created":"2023-05-15T14:51:22.827581+00:00","id":70240,"links":{},"metadata":{"_buckets":{"deposit":"7dfeca81-518c-4956-b511-9a10fae95208"},"_deposit":{"created_by":1,"id":"70240","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70240"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070240","sets":["10:28"]},"author_link":["689727","689721","689726","689728","689730","689725","689731","689722","689720","689729","689724","689723"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-09-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To develop a selective diagnostic imaging of mesothelioma by targeting disease-specific biomarkers.\nMaterials and Methods: All experiments were approved by the Institutional Animal Care and Use Committee. Manganese-superoxide dismutase (Mn-SOD) expression was evaluated in one human mesothelial cells and five human malignant mesothelioma (MM) cells. Mn accumulation in NCI-H226 and MSTO-211H MM cells was examined when loaded with Mn. Mn-enhanced magnetic resonance imaging (MEMRI) of those cell pellets and subcutaneous tumors were conducted using 7 Tesla-MRI. Signal enhancement of H226 xenografted pleural tumors was determined by MEMRI with manganese dipyridoxyl diphosphate (MnDPDP) as well as manganese chloride (MnCl2). \nResults: We found that 4 of 5 human MM cells over-expressed Mn-SOD protein compared to mesothelial cells, and that H226 MM cells highly expressed Mn-SOD and augmented Mn accumulation when loaded with MnCl2. The cells showed marked T1-signal enhancement on in vitro MRI after incubation with MnCl2. H226 subcutaneous tumors were preferentially enhanced compared to MSTO-211H tumors, which had less Mn-SOD expression, in MnCl2-enhanced T1-weighted MR image (T1WI). H226 pleural tumors were markedly enhanced and readily detected by MEMRI using MnDPDP as well as MnCl2.\nConclusion: We propose that MEMRI can be a potentially powerful method for non-invasive detection of MM with high spatial resolution and marked signal enhancement by targeting Mn-SOD.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"World  Molecular Imaging Congress 2010","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka"}],"nameIdentifiers":[{"nameIdentifier":"689720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Shigeyoshi"}],"nameIdentifiers":[{"nameIdentifier":"689721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morokoshi, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"689722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"689723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"689724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"689725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 茂芳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"諸越 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"689731","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Manganese-enhanced MRI as a molecular imaging of mesothelioma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Manganese-enhanced MRI as a molecular imaging of mesothelioma"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-09-14"},"publish_date":"2010-09-14","publish_status":"0","recid":"70240","relation_version_is_last":true,"title":["Manganese-enhanced MRI as a molecular imaging of mesothelioma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:05:15.198887+00:00"}