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INDUCTION OF DNA DSB AND ITS REJOINING IN THE CLAMPED AND NON-CLAMPED TUMORS AFTER CARBON ION BEAMS COMPARED WITH X RAYS
https://repo.qst.go.jp/records/69928
https://repo.qst.go.jp/records/699283c1b1074-b40c-4b4c-9276-071dd6de7d5d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-11-09 | |||||
| タイトル | ||||||
| タイトル | INDUCTION OF DNA DSB AND ITS REJOINING IN THE CLAMPED AND NON-CLAMPED TUMORS AFTER CARBON ION BEAMS COMPARED WITH X RAYS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Uzawa, Akiko× Matsumoto, Yoshitaka× Noguchi, Miho× Kase, Yuuki× Ito, Atsushi× Okayasu, Ryuichi× Koike, Sachiko× Ando, Koichi× Furusawa, Yoshiya× 平山 亮一× 鵜澤 玲子× 松本 孔貴× 加瀬 優紀× 伊藤 敦× 岡安 隆一× 小池 幸子× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We studied DSB induction and rejoining in the clamped and non-clamped tumors after low- and high-LET radiations. SCCVII cells were transplanted into the right hind legs of C3H male mice. Conditioning irradiation with either 80 keV/μm carbon ions or 200 kVp X rays was delivered to the tumors at 5 mm diameter. Hypoxic cells were produced by clamping tumor-bearing mice 15min before irradiation in situ. Immediately after and 1 hr after irradiation, tumors were excised and rapidly cooled on ice. DSB in the tumors was analyzed by a static-field gel electrophoresis, and assayed for DSB induction and rejoining. The DSB immediately after X rays under normoxic condition was higher than under hypoxic condition. These damages in both tumor conditions were rejoined 60 to 70% within 1 hr in situ. The OER of DSB after X rays was 1.68 ± 0.31, and this value was not changed by 1 hr rejoining incubation (1.40 ± 0.26). On the other hand, no difference between X rays and carbon ions was found for the induction and rejoining of DSB. The rejoined fraction and the OER of DSB after carbon ions were similar to that after X rays. Additionally, the RBE of DSB immediately after and 1 hr after irradiation, these values were 0.9 to 1.3, and were not dependent on gases conditions. The yields of DSB induced by X rays in vivo might be similar to that after carbon ions, because the OER and RBE were not found a major difference. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | MICROS 2009 15th International Symposium on Microdosimetry | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-30 | |||||
| 日付タイプ | Issued | |||||
